Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC

Candida glabrata strains sequentially isolated from blood developed resistance to micafungin (MICs from <0.015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1.

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Detalhes bibliográficos
Main Authors: Saraya, Takeshi, Tanabe, Koichi, Araki, Koji, Yonetani, Shota, Makino, Hiroshi, Watanabe, Takayasu, Tsujimoto, Naoki, Takata, Saori, Kurai, Daisuke, Ishii, Haruyuki, Miyazaki, Yoshitsugu, Takizawa, Hajime, Goto, Hajime
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Case Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097732/
https://ncbi.nlm.nih.gov/pubmed/24789192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.03593-13
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