Specific α-Arrestins Negatively Regulate Saccharomyces cerevisiae Pheromone Response by Down-Modulating the G-Protein-Coupled Receptor Ste2

G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate responses to extracellular stimuli by mediating ligand-dependent activation of cognate heterotrimeric G proteins. In yeast, occupancy of GPCR Ste2 by peptide pheromone α-factor initiates signaling by releasing a stimula...

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Main Authors: Alvaro, Christopher G., O'Donnell, Allyson F., Prosser, Derek C., Augustine, Andrew A., Goldman, Aaron, Brodsky, Jeffrey L., Cyert, Martha S., Wendland, Beverly, Thorner, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097657/
https://ncbi.nlm.nih.gov/pubmed/24820415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00230-14
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