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Bim Regulates Alloimmune-Mediated Vascular Injury Through Effects on T Cell Activation and Death

OBJECTIVE: Bim is a pro-apoptotic Bcl-2 protein known to down-regulate immune responses and to also be required for antigen-induced T cell activation. However, it is not known how the effect of Bim on these offsetting processes determines the outcome of allogeneic immune responses. We have defined t...

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Bibliographic Details
Main Authors: von Rossum, Anna, Enns, Winnie, Shi, Yu P., MacEwan, Grace E., Malekesmaeli, Mehrnoush, Brinkman, Ryan, Choy, Jonathan C.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097606/
https://ncbi.nlm.nih.gov/pubmed/24700126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303649
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