Glutaminase Catalyses Reaction of Glutamate to GABA

Here, for the first time, we report an NMR spectroscopy study of L-Glutamine (Gln) conversion by Glutaminase (Glnase), which shows that the reaction involves two distinct steps. In the first step, Glnase rapidly hydrolyses Gln to Glutamate (Glu) (~16.87 μmol of Gln/min/mg of Glnase) and in the secon...

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Bibliografiske detaljer
Main Authors: Nanga, Ravi Prakash Reddy, DeBrosse, Catherine, Singh, Anup, D’Aquilla, Kevin, Hariharan, Hari, Reddy, Ravinder
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097173/
https://ncbi.nlm.nih.gov/pubmed/24755074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.04.059
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