Identification of Functional Amino Acid Residues Involved in Polyamine and Agmatine Transport by Human Organic Cation Transporter 2

Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. The Km values for putrescine and spermidine were 7.50 and 6.76 mM, and the Vmax values were 4.71 and 2.34 nmol/min/mg...

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Autors principals: Higashi, Kyohei, Imamura, Masataka, Fudo, Satoshi, Uemura, Takeshi, Saiki, Ryotaro, Hoshino, Tyuji, Toida, Toshihiko, Kashiwagi, Keiko, Igarashi, Kazuei
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096761/
https://ncbi.nlm.nih.gov/pubmed/25019617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102234
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