Epistatic Interaction of ERAP1 and HLA-B in Behçet Disease: A Replication Study in the Spanish Population

Behçet's disease (BD) is a multifactorial disorder associated with the HLA region. Recently, the ERAP1 gene has been proposed as a susceptibility locus with a recessive model and with epistatic interaction with HLA-B51. ERAP1 trims peptides in the endoplasmic reticulum to optimize their length...

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Main Authors: Conde-Jaldón, Marta, Montes-Cano, Marco Antonio, García-Lozano, José Raul, Ortiz-Fernández, Lourdes, Ortego-Centeno, Norberto, González-León, Rocío, Espinosa, Gerard, Graña-Gil, Genaro, Sánchez-Bursón, Juan, González-Gay, Miguel Angel, Barnosi-Marín, Ana Celia, Solans, Roser, Fanlo, Patricia, Carballeira, Mónica Rodríguez, Camps, Teresa, Castañeda, Santos, Martín, Javier, González-Escribano, María Francisca
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096596/
https://ncbi.nlm.nih.gov/pubmed/25019531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102100
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