Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy

[Image: see text] Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two warheads, self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety, and 1,3,5-triazine as the trip...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Vineberg, Jacob G., Zuniga, Edison S., Kamath, Anushree, Chen, Ying-Jen, Seitz, Joshua D., Ojima, Iwao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2014
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096217/
https://ncbi.nlm.nih.gov/pubmed/24901491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500631u
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