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Staufen1 dimerizes via a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay
Staufen (STAU)1-mediated mRNA decay (SMD) degrades mammalian-cell mRNAs that bind the double-stranded (ds)RNA-binding protein STAU1 in their 3′-untranslated region. We report a new motif, which typifies STAU homologs from all vertebrate classes, that is responsible for human (h)STAU1 homodimerizatio...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096160/ https://ncbi.nlm.nih.gov/pubmed/23524536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2528 |
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