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Decreased proliferative capacity of aged dermal fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation

Skin aging results in increased susceptibility to injury and impaired wound healing. Proliferation of fibroblasts is reduced in aged dermis, which contributes to delays in wound closure. Age-associated differences are regulated, in part, by local or systemic factors such as the IGF-1/IGF1R system. T...

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Bibliografski detalji
Glavni autori: Bentov, Itay, Damodarasamy, Mamatha, Plymate, Stephen, Reed, May J
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096050/
https://ncbi.nlm.nih.gov/pubmed/24770843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10522-014-9501-8
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