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Addition of a Second Binding Site Increases the Dynamic Range but Alters the Cellular Localization of a Red Fluorescent Probe for Mobile Zinc

[Image: see text] We report the synthesis and photophysical properties of ZBR4 and ZR1, two resorufin-based ditopic probes for mobile zinc. Upon binding Zn(2+), the sensors display 14- and 41-fold enhancements of their red fluorescence emission, respectively. In contrast to ZR1 and other members of...

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Detalhes bibliográficos
Main Authors: Loas, Andrei, Radford, Robert J., Lippard, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095928/
https://ncbi.nlm.nih.gov/pubmed/24915285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic500732z
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