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How Multi-Organ Microdevices Can Help Foster Drug Development

Multi-organ microdevices can mimic tissue-tissue interactions that occur as a result of metabolite travel from one tissue to other tissues in vitro. These systems are capable of simulating human metabolism, including the conversion of a pro-drug to its effective metabolite as well as its subsequent...

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Bibliografiske detaljer
Main Authors: Esch, Mandy B., Smith, Alec, Prot, Jean-Matthieu, Sancho, Carlotta Oleaga, Hickman, James, Shuler, Michael L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095890/
https://ncbi.nlm.nih.gov/pubmed/24412641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2013.12.003
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