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Zn(2+) efflux through lysosomal exocytosis prevents Zn(2+)-induced toxicity

Zn(2+) is an essential micronutrient and an important ionic signal whose excess, as well as scarcity, is detrimental to cells. Free cytoplasmic Zn(2+) is controlled by a network of Zn(2+) transporters and chelating proteins. Recently, lysosomes became the focus of studies in Zn(2+) transport, as the...

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Autores principales: Kukic, Ira, Kelleher, Shannon L., Kiselyov, Kirill
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095854/
https://ncbi.nlm.nih.gov/pubmed/24829149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.145318
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