Hepatic Stellate Cell Coculture Enables Sorafenib Resistance in Huh7 Cells through HGF/c-Met/Akt and Jak2/Stat3 Pathways

Purpose. Tumor microenvironment confers drug resistance to kinase inhibitors by increasing RKT ligand levels that result in the activation of cell-survival signaling including PI3K and MAPK signals. We assessed whether HSC-LX2 coculture conferred sorafenib resistance in Huh7 and revealed the mechani...

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Detalhes bibliográficos
Main Authors: Chen, Weibo, Wu, Junhua, Shi, Hua, Wang, Zhongxia, Zhang, Guang, Cao, Yin, Jiang, Chunping, Ding, Yitao
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095710/
https://ncbi.nlm.nih.gov/pubmed/25057499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/764981
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