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The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

Prolonged exposure to melatonin improves glycemic control in animals. Although glucose metabolism is controlled by circadian clock genes, little is known about the role of melatonin signaling and its duration in the regulation of clock gene expression in pancreatic β-cells. Activation of MT(1) and M...

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Bibliografiske detaljer
Main Authors: Nishiyama, Keiji, Hirai, Keisuke
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094524/
https://ncbi.nlm.nih.gov/pubmed/25013953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102073
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