Correlation between In Vitro Cytotoxicity and In Vivo Lethal Activity in Mice of Epsilon Toxin Mutants from Clostridium perfringens

Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations. Site-specific mutations of the toxin are valuable tools to study the cellular and molecular mechan...

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Hlavní autoři: Dorca-Arévalo, Jonatan, Pauillac, Serge, Díaz-Hidalgo, Laura, Martín-Satué, Mireia, Popoff, Michel R., Blasi, Juan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094505/
https://ncbi.nlm.nih.gov/pubmed/25013927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102417
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