Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

[Image: see text] A cis-configured 3,5-disubstituted piperidine direct renin inhibitor, (syn,rac)-1, was discovered as a high-throughput screening hit from a target-family tailored library. Optimization of both the prime and the nonprime site residues flanking the central piperidine transition-state...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ehara, Takeru, Irie, Osamu, Kosaka, Takatoshi, Kanazawa, Takanori, Breitenstein, Werner, Grosche, Philipp, Ostermann, Nils, Suzuki, Masaki, Kawakami, Shimpei, Konishi, Kazuhide, Hitomi, Yuko, Toyao, Atsushi, Gunji, Hiroki, Cumin, Frederic, Schiering, Nikolaus, Wagner, Trixie, Rigel, Dean F., Webb, Randy L., Maibaum, Jürgen, Yokokawa, Fumiaki
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2014
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094259/
https://ncbi.nlm.nih.gov/pubmed/25050166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500137b
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन