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The Chemical Uncoupler 2,4-Dinitrophenol (DNP) Protects against Diet-induced Obesity and Improves Energy Homeostasis in Mice at Thermoneutrality

The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug in the early 1930s. However, the physiology of DNP has not been studied in detail because toxicity, including hyperthermia and death, reduced interest in the clinical use of chemical uncouplers. To inves...

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Autors principals: Goldgof, Margalit, Xiao, Cuiying, Chanturiya, Tatyana, Jou, William, Gavrilova, Oksana, Reitman, Marc L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094046/
https://ncbi.nlm.nih.gov/pubmed/24872412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568204
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