Cytochrome P450 3A and P-glycoprotein drug–drug interactions with voclosporin

AIMS: Voclosporin is a novel calcineurin inhibitor intended for prevention of organ graft rejection and treatment of lupus nephritis. Pharmacokinetic drug interactions between voclosporin and a CYP3A inhibitor, inducer and substrate and a P-glycoprotein inhibitor and substrate were evaluated. METHOD...

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Bibliographic Details
Main Authors: Ling, Spencer Y, Huizinga, Robert B, Mayo, Patrick R, Larouche, Richard, Freitag, Derrick G, Aspeslet, Launa J, Foster, Robert T
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2014
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093929/
https://ncbi.nlm.nih.gov/pubmed/24330024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12309
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