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Hantaan virus nucleocapsid protein stimulates MDM2-dependent p53 degradation

Apoptosis has been shown to be induced and downregulated by the Hantaan virus (HTNV) nucleocapsid (N) protein. To address these conflicting data, expression of the p53 protein, one of the key molecules involved in apoptosis, was assessed in the presence of the N protein in A549 and HeLa cells. The a...

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Detalhes bibliográficos
Main Authors: Park, Sun-Whan, Han, Myung-Guk, Park, Chan, Ju, Young Ran, Ahn, Byung-Yoon, Ryou, Jungsang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093783/
https://ncbi.nlm.nih.gov/pubmed/23994832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.054312-0
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