Electrocardiograms (ECGs) in phase I anticancer drug development: the MD Anderson Cancer Center experience with 8518 ECGs

BACKGROUND: Cardiac sequelae from oncologic drugs are important in early cancer drug development. Prolongation of the corrected QT interval (QTc) by noncardiac drugs is the most common cause of drug development delays, nonapprovals and postmarketing withdrawals by the US Food and Drug Administration...

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Detalhes bibliográficos
Main Authors: Naing, A., Veasey-Rodrigues, H., Hong, D. S., Fu, S., Falchook, G. S., Wheler, J. J., Tsimberidou, A. M., Wen, S., Fessahaye, S. N., Golden, E. C., Aaron, J., Ewer, M. S., Kurzrock, R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
original articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092255/
https://ncbi.nlm.nih.gov/pubmed/22745218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mds130
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