Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells

Experimental evolution has been used for various biotechnological applications including protein and microbial cell engineering, but less commonly in the field of oncolytic virotherapy. Here, we sought to adapt a rapidly evolving RNA virus to cells deficient for the tumor suppressor gene p53, a hall...

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Bibliographic Details
Main Authors: Garijo, Raquel, Hernández-Alonso, Pablo, Rivas, Carmen, Diallo, Jean-Simon, Sanjuán, Rafael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092128/
https://ncbi.nlm.nih.gov/pubmed/25010337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102365
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