Sox11 Is Required to Maintain Proper Levels of Hedgehog Signaling during Vertebrate Ocular Morphogenesis

Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical role in choro...

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Main Authors: Pillai-Kastoori, Lakshmi, Wen, Wen, Wilson, Stephen G., Strachan, Erin, Lo-Castro, Adriana, Fichera, Marco, Musumeci, Sebastiano A., Lehmann, Ordan J., Morris, Ann C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091786/
https://ncbi.nlm.nih.gov/pubmed/25010521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004491
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