Hypersensitivity of Primordial Germ Cells to Compromised Replication-Associated DNA Repair Involves ATM-p53-p21 Signaling

Genome maintenance in germ cells is critical for fertility and the stable propagation of species. While mechanisms of meiotic DNA repair and chromosome behavior are well-characterized, the same is not true for primordial germ cells (PGCs), which arise and propagate during very early stages of mammal...

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Detalhes bibliográficos
Main Authors: Luo, Yunhai, Hartford, Suzanne A., Zeng, Ruizhu, Southard, Teresa L., Shima, Naoko, Schimenti, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091704/
https://ncbi.nlm.nih.gov/pubmed/25010009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004471
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