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MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling
Retinoic acid-inducible protein I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are cytosolic viral RNA sensors that induce type I interferon production (IFN). In this study, we found that MDA5 undergoes inducible SUMOylation by small ubiquitin-like modifier-1 (SUMO-1) in response to...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4091678/ https://ncbi.nlm.nih.gov/pubmed/21156324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2010.09.003 |
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