Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

Nonresolving inflammation in the intestine predisposes individuals to the development of colitis-associated cancer (CAC). Inflammasomes are thought to mediate intestinal homeostasis, and their dysregulation contributes to inflammatory bowel diseases and CAC. However, few agents have been reported to...

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Autors principals: Guo, Wenjie, Sun, Yang, Liu, Wen, Wu, Xingxin, Guo, Lele, Cai, Peifen, Wu, Xuefeng, Wu, Xudong, Shen, Yan, Shu, Yongqian, Gu, Yanhong, Xu, Qiang
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Basic Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091180/
https://ncbi.nlm.nih.gov/pubmed/24879148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28374
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