Absence of PKC-Alpha Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus

Lithium, an effective antipsychotic, induces nephrogenic diabetes insipidus (NDI) in ∼40% of patients. The decreased capacity to concentrate urine is likely due to lithium acutely disrupting the cAMP pathway and chronically reducing urea transporter (UT-A1) and water channel (AQP2) expression in the...

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Main Authors: Sim, Jae H., Himmel, Nathaniel J., Redd, Sara K., Pulous, Fadi E., Rogers, Richard T., Black, Lauren N., Hong, Seongun M., von Bergen, Tobias N., Blount, Mitsi A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090211/
https://ncbi.nlm.nih.gov/pubmed/25006961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101753
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