Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial

TRIAL DESIGN: HIV-1 vaccine development has advanced slowly due to viral antigenic diversity, poor immunogenicity and recently, safety concerns associated with human adenovirus serotype-5 vectors. To tackle HIV-1 variation, we designed a unique T-cell immunogen HIVconsv from functionally conserved r...

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Autors principals: Hayton, Emma-Jo, Rose, Annie, Ibrahimsa, Umar, Del Sorbo, Mariarosaria, Capone, Stefania, Crook, Alison, Black, Antony P., Dorrell, Lucy, Hanke, Tomáš
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090156/
https://ncbi.nlm.nih.gov/pubmed/25007091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101591
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