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Thermodynamics of Water in an Enzyme Active Site: Grid-Based Hydration Analysis of Coagulation Factor Xa
[Image: see text] Water molecules in the active site of an enzyme occupy a complex, heterogeneous environment, and the thermodynamic properties of active-site water are functions of position. As a consequence, it is thought that an enzyme inhibitor can gain affinity by extending into a region occupi...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089914/ https://ncbi.nlm.nih.gov/pubmed/25018673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct401110x |
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