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Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
Prostaglandin E2 (PGE2) promotes Th17 expansion while otherwise inhibiting other CD4(+) T cell subsets. Here, we identified a PGE2-dependent pathway that induces pathogenic Th17 cells in autoimmune disease and is regulated by the transcription factor RORC. Compared with other CD4(+) cell types from...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089462/ https://ncbi.nlm.nih.gov/pubmed/24812667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72973 |
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