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Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
Tregs control various functions of effector T cells; however, where and how Tregs exert their immunomodulatory effects remain poorly understood. Here we developed a murine model of adoptive T cell therapy and found that Tregs induce a dysfunctional state in tumor-infiltrating CTLs that resembles T c...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4089459/ https://ncbi.nlm.nih.gov/pubmed/24812664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66375 |
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