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A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock
Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the inflammatory response and plays a role in cancer and sepsis. Inhibition of TREM-1 by short hairpin RNA (shRNA) in macrophages suppresses cancer cell invasion in vitro. In the clinical setting, high levels of TREM-1 expression on...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4088342/ https://ncbi.nlm.nih.gov/pubmed/24836682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2014.05.001 |
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