S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism

AIM: To determine the role of c-Jun N-terminal kinase (JNK) activity in ethanol-induced apoptosis and the modulation of this signaling cascade by S-Adenosyl-methionine (AdoMet). METHODS: Primary hepatocyte cultures were pretreated with 100 µmol/L SP600125, a selective JNK inhibitor, 1 mL/L DMSO or 4...

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Detalhes bibliográficos
Main Authors: Cabrales-Romero, María del Pilar, Márquez-Rosado, Lucrecia, Fattel-Fazenda, Samia, Trejo-Solís, Cristina, Arce-Popoca, Evelia, Alemán-Lazarini, Leticia, Villa-Treviño, Saúl
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Co., Limited 2006
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087515/
https://ncbi.nlm.nih.gov/pubmed/16609996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v12.i12.1895
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