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Interim analysis for binary outcome trials with a long fixed follow-up time and repeated outcome assessments at pre-specified times

In trials with binary outcomes, assessed repeatedly at pre-specified times and where the subject is considered to have experienced a failure at the first occurrence of the outcome, interim analyses are performed, generally, after half or more of the subjects have completed follow-up. Depending on th...

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Autors principals: Parpia, Sameer, Julian, Jim A, Gu, Chushu, Thabane, Lehana, Levine, Mark N
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087327/
https://ncbi.nlm.nih.gov/pubmed/25019050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2193-1801-3-323
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