T cells redirected to IL13Rα2 with IL13 mutein-CARs have antiglioma activity but also recognize IL13Rα1

Outcomes for patients with glioblastoma remain poor despite aggressive multimodal therapy. Immunotherapy with genetically modified T cells expressing chimeric antigen receptors (CARs) targeting IL13R[.alpha]2, HER2, EGFRvIII, or EphA2 has shown promise for the treatment of glioma in preclinical mode...

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Bibliographische Detailangaben
Hauptverfasser: Krebs, Simone, Chow, Kevin KH, Yi, Zongzhen, Rodriguez-Cruz, Tania, Hegde, Meenakshi, Gerken, Claudia, Ahmed, Nabil, Gottschalk, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087074/
https://ncbi.nlm.nih.gov/pubmed/24841514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2014.02.012
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