Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3′-Deoxy-3′-[(18)F]-Fluorothymidine Cellular Retention

BACKGROUND: 3′-Deoxy-3′-[(18)F]-fluorothymidine ([(18)F]FLT) is being investigated as a Positron Emission Tomography (PET) proliferation biomarker. The mechanism of cellular [(18)F]FLT retention has been assigned primarily to alteration of the strict transcriptionally regulated S-phase expression of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sala, Roberta, Nguyen, Quang-Dé, Patel, Chirag B. K., Mann, David, Steinke, Joachim H. G., Vilar, Ramon, Aboagye, Eric O.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086825/
https://ncbi.nlm.nih.gov/pubmed/25003822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101366
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg