Mucosal Imprinting of Vaccine-Induced CD8(+) T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Although many human cancers are located in mucosal sites, most cancer vaccines are tested against subcutaneous tumors in preclinical models. We therefore wondered whether mucosa-specific homing instructions to the immune system might influence mucosal tumor outgrowth. We showed that the growth of or...

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Autori principali: Sandoval, Federico, Terme, Magali, Nizard, Mevyn, Badoual, Cécile, Bureau, Michel-Francis, Freyburger, Ludovic, Clement, Olivier, Marcheteau, Elie, Gey, Alain, Fraisse, Guillaume, Bouguin, Cécilia, Merillon, Nathalie, Dransart, Estelle, Tran, Thi, Quintin-Colonna, Françoise, Autret, Gwennhael, Thiebaud, Marine, Suleman, Muhammad, Riffault, Sabine, Wu, Tzyy-Choou, Launay, Odile, Danel, Claire, Taieb, Julien, Richardson, Jennifer, Zitvogel, Laurence, Fridman, Wolf H., Johannes, Ludger, Tartour, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086646/
https://ncbi.nlm.nih.gov/pubmed/23408053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004888
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