Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer

BACKGROUND & AIMS: Activation of the transcription factor NFκB has been associated with development of inflammatory bowel disease (IBD). COMMD1, a regulator of various transport pathways, has been shown to limit NFκB activation. We investigated the roles of COMMD1 in the pathogenesis of colitis...

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Hauptverfasser: Li, Haiying, Chan, Lillienne, Bartuzi, Paulina, Melton, Shelby D., Weber, Axel, Ben-Shlomo, Shani, Varol, Chen, Raetz, Megan, Mao, Xicheng, Starokadomskyy, Petro, van Sommeren, Suzanne, Mokadem, Mohamad, Schneider, Heike, Weisberg, Reid, Westra, Harm-Jan, Esko, Tõnu, Metspalu, Andres, Kumar, Vinod, Faubion, William A., Yarovinsky, Felix, Hofker, Marten, Wijmenga, Cisca, Kracht, Michael, Franke, Lude, Aguirre, Vincent, Weersma, Rinse K., Gluck, Nathan, van de Sluis, Bart, Burstein, Ezra
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086320/
https://ncbi.nlm.nih.gov/pubmed/24727021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.04.007
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