A Phase I Study of Bevacizumab (B) in Combination with Everolimus (E) and Erlotinib (E) in Advanced Cancer (BEE)

PURPOSE: VEGF, mTOR, and EGFR inhibitors have demonstrated anti-tumor and anti-angiogenic effects alone and in combination with each other. This study evaluated the safety, tolerability, and pharmacokinetics of bevacizumab, everolimus and erlotinib combination. METHODS: Doublet therapy consisted of...

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Main Authors: Bullock, Karen E., Petros, William P., Younis, Islam, Uronis, Hope E., Morse, Michael A., Blobe, Gerard C., Zafar, S. Yousuf, Gockerman, Jon P., Lager, Joanne J., Truax, Roxanne, Meadows, Kellen L., Howard, Leigh A., O’Neill, Margot M., Broadwater, Gloria, Hurwitz, Herbert I., Bendell, Johanna C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086252/
https://ncbi.nlm.nih.gov/pubmed/21079958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1507-6
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