The Role of Complement in Age-Related Macular Degeneration: Heparan Sulphate, a ZIP Code for Complement Factor H?

Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations and has been associated with complement dysregulation in the central retina. The Y402H polymorphism in the complement regulatory protein factor H (CFH) can confer a >5-fold increased risk of developing A...

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Autores principales: Langford-Smith, Alex, Keenan, Tiarnan D.L., Clark, Simon J., Bishop, Paul N., Day, Anthony J.
Formato: Artigo
Lenguaje:Inglês
Publicado: S. Karger AG 2014
Materias:
Review
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086042/
https://ncbi.nlm.nih.gov/pubmed/24335201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000356513
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