The Role of Complement in Age-Related Macular Degeneration: Heparan Sulphate, a ZIP Code for Complement Factor H?

Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations and has been associated with complement dysregulation in the central retina. The Y402H polymorphism in the complement regulatory protein factor H (CFH) can confer a >5-fold increased risk of developing A...

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Библиографические подробности
Главные авторы: Langford-Smith, Alex, Keenan, Tiarnan D.L., Clark, Simon J., Bishop, Paul N., Day, Anthony J.
Формат: Artigo
Язык:Inglês
Опубликовано: S. Karger AG 2014
Предметы:
Review
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086042/
https://ncbi.nlm.nih.gov/pubmed/24335201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000356513
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