The Role of Complement in Age-Related Macular Degeneration: Heparan Sulphate, a ZIP Code for Complement Factor H?

Age-related macular degeneration (AMD) is the leading cause of blindness in developed nations and has been associated with complement dysregulation in the central retina. The Y402H polymorphism in the complement regulatory protein factor H (CFH) can confer a >5-fold increased risk of developing A...

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Bibliographic Details
Main Authors: Langford-Smith, Alex, Keenan, Tiarnan D.L., Clark, Simon J., Bishop, Paul N., Day, Anthony J.
Format: Artigo
Language:Inglês
Published: S. Karger AG 2014
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4086042/
https://ncbi.nlm.nih.gov/pubmed/24335201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000356513
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