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Renal cytochrome P450 ω-hydroxylase and epoxygenase activity are differentially modified by nitric oxide and sodium chloride

Renal function is perturbed by inhibition of nitric oxide synthase (NOS). To probe the basis of this effect, we characterized the effects of nitric oxide (NO), a known suppressor of cytochrome P450 (CYP) enzymes, on metabolism of arachidonic acid (AA), the expression of ω-hydroxylase, and the efflux...

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Podrobná bibliografie
Vydáno v:J Clin Invest
Hlavní autoři: Oyekan, A.O., Youseff, T., Fulton, D., Quilley, J., McGiff, J.C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408575/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10525052/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6786
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