The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients

BACKGROUND: Toll-like receptor 4 (TLR4), a lipopolysaccharide (LPS) receptor complex signal-transducing molecule, plays a crucial role in sensing LPS from gram-negative bacteria. TLR4 signaling pathway activation by LPS plays a major role in sepsis pathogenesis. A single nucleotide polymorphism, rs1...

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Bibliografiske detaljer
Main Authors: Mansur, Ashham, Gruben, Luisa von, Popov, Aron F, Steinau, Maximilian, Bergmann, Ingo, Ross, Daniel, Ghadimi, Michael, Beissbarth, Tim, Bauer, Martin, Hinz, José
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085654/
https://ncbi.nlm.nih.gov/pubmed/24950711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-177
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