Examining Variation in Recombination Levels in the Human Female: A Test of the Production-Line Hypothesis

The most important risk factor for human aneuploidy is increasing maternal age, but the basis of this association remains unknown. Indeed, one of the earliest models of the maternal-age effect—the “production-line model” proposed by Henderson and Edwards in 1968—remains one of the most-cited explana...

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Autores principales: Rowsey, Ross, Gruhn, Jennifer, Broman, Karl W., Hunt, Patricia A., Hassold, Terry
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085639/
https://ncbi.nlm.nih.gov/pubmed/24995869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2014.06.008
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