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Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

The majority of thyroid carcinomas maintain the expression of the cell growth suppressor p27, an inhibitor of cyclin-dependent kinase-2 (Cdk2). However, we find that 80% of p27-expressing tumors show an uncommon cytoplasmic localization of p27 protein, associated with high Cdk2 activity. To reproduc...

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Udgivet i:J Clin Invest
Principais autores: Baldassarre, Gustavo, Belletti, Barbara, Bruni, Paola, Boccia, Angelo, Trapasso, Francesco, Pentimalli, Francesca, Barone, Maria Vittoria, Chiappetta, Gennaro, Vento, Maria Teresa, Spiezia, Stefania, Fusco, Alfredo, Viglietto, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408550/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10510327/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6443
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