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Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development

Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to and activate the same PTH/PTHrP receptor. Deletion of either the PTHrP gene or the PTH/PTHrP receptor gene leads to acceleration of differentiation of growth plate chondrocytes. To explore further the functional relati...

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Udgivet i:J Clin Invest
Principais autores: Lanske, Beate, Amling, Michael, Neff, Lynn, Guiducci, Jennifer, Baron, Roland, Kronenberg, Henry M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408525/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10449432/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6629
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