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Ugi 4–CR Synthesis of γ– and δ–Lactams providing new access to diverse enzyme interactions, a PDB analysis
A three step synthesis of N-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted γ- and δ-lactam fragment reveals a strongly t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084911/ https://ncbi.nlm.nih.gov/pubmed/25013719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00162A |
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