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Deficiency of the Cog8 Subunit in Normal and CDG-Derived Cells Impairs the Assembly of the COG and Golgi SNARE Complexes

Multiple mutations in different subunits of the tethering complex Conserved Oligomeric Golgi (COG) have been identified as a cause for Congenital Disorders of Glycosylation (CDG) in humans. Yet, the mechanisms by which COG mutations induce the pleiotropic CDG defects have not been fully defined. By...

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Detalhes bibliográficos
Main Authors: Laufman, Orly, Freeze, Hudson H., Hong, Wanjin, Lev, Sima
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084554/
https://ncbi.nlm.nih.gov/pubmed/23865579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12093
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