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SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line
The Caenorhabditis elegans LSD1 H3K4me2 demethylase SPR-5 reprograms epigenetic transcriptional memory during passage through the germ line. Here we show that mutants in the H3K9me2 methyltransferase, met-2, result in transgenerational epigenetic effects that parallel spr-5 mutants. In addition, we...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084444/ https://ncbi.nlm.nih.gov/pubmed/24979765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321843111 |
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