A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II–stimulated vascular smooth muscle cell hypertrophy

Angiotensin II (Ang II) has been shown to stimulate either hypertrophy or hyperplasia. We postulated that the differential response of vascular smooth muscle cells (VSMCs) to Ang II is mediated by the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1), which is abundant in quiescent cells and drops a...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Braun-Dullaeus, Ruediger C., Mann, Michael J., Ziegler, Almut, von der Leyen, Heiko E., Dzau, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1999
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Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC408428/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10491417/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5339
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